We use a translational approach that combines rodent models, non-human primates, and human data to explore how metabolic or vascular perturbations affect the progression of Alzheimer’s disease. For our rodent studies, we use a variety of in vivo techniques, including glucose clamps, in vivo microdialysis, in vivo biosensors, EEG/EMG recordings, and small animal neuroimaging to study the acute effects of metabolic challenges on Aβ/tau dynamics, cerebral metabolism, neuronal activity, neurovascular coupling, and sleep. We also use rodent models and non-human primates to investigate how different Alzheimer’s risk factors impact pathology, metabolism, brain network connectivity, and behavior.

Our ultimate goal is to explore pharmacological and non-pharmacological interventions targeting metabolic dysfunction reverse pathology and functional deficits in Alzheimer’s disease.